op basel



A in petroleum spirit.

Patented Jan. 10, 1928.

UNITED STATES PATENT OFFICE.

FRITZ Itl'LLER, OF BASEL, SWITZERLAND, ASSIGNOR TO CHEMICAL WORKS FORMERLY SANDOZ, 01" BASEL, SWITZERLAND, A FIRM.

PHARMACEUTICAL PRODUCT.

No Drawing. Application filed May 18, 1927, Serial No. 192,484, and in Switzerland June 3, 1826.

This invention relates to the manufacturev of a new pharmaceutical product, being a double compound of allylisobutylbarbituric acid of the formula:

CHz= CILGH:

CO-NH Gila-( 3 .N

\CH: The new compound forms a, yellowish crystalline powder, which is-soluble in alcohol, methanol, ether, practically insoluble It possesses valuable hypnotic and analgetic properties.

It is obtained by allowing the above mentioned substances to react on each other, either insolution or by melting them to gether.

Example 1.

231 parts by weight of l-phenyl-2, 3-dimethyl-4-dimethylan1ino-5-pyrazol0n and 224 parts by weight of allylisobutylbarbituric Ewample 2.

231 parts by weight of l-phenyl-Q, 3-dimethyl-4-dimethylan1ino-5-pyrazolon and 224 parts by weight of allylisobu'tylbarbituric methanol. When concentrating the solution the new double compound separates.

sisting of allylisobutylbarbituric acid and 1- phenyl-2, 3-diniethyl-4-dimethylamino-5- p razolon, 'which compound forms a yellowish crystalllne powder and is soluble in alcohol, methanol, ether, practically insoluble in petroleum spirit, possessing valuable .hy notic and analgetic properties, substanti y as described.

In witness whereof I have hereunto signed my name this7th day'of May, 1927.

' FRITZ MULLER.

acld are dissolved in suflicient quantities of '45 

